Diurnal variation of urinary markers of nucleic acid oxidation.

  title={Diurnal variation of urinary markers of nucleic acid oxidation.},
  author={Ida S Grew and Vanja Cejvanovic and Kasper Broedbaek and Trine N{\ae}ss Henriksen and Morten Petersen and Jon Tr{\ae}rup Andersen and Espen Jimenez-Solem and Allan Weimann and Henrik Enghusen Poulsen},
  journal={Scandinavian journal of clinical and laboratory investigation},
  volume={74 4},
AIMS Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) are biomarkers of oxidative stress with clinical potential in a variety of diseases. As part of their clinical validation, this study aimed to investigate whether the urinary excretion of 8-oxodG and 8-oxoGuo undergoes diurnal variation and to evaluate the validity of 6-hour sampling as well as creatinine corrected spot urine sampling. METHODS A total of 23 healthy study subjects collecting… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 15 references

Human and methodological sources of variability in the measurement of urinary 8Oxo7 , 8dihydro2 ′deoxyguanosine

  • EL Kanabrocki, D Murray, +8 authors DC Hooper
  • Antioxid Redox Signal
  • 2013

Auto - [ 3 ] mated method for the direct analysis of 8oxoguanosine and 8oxo2 ′deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry

  • T Henriksen, PR Hillestrom, HE Poulsen, A Weimann
  • Free Radic Biol Med
  • 2009

Similar Papers

Loading similar papers…