Diurnal variation of urinary markers of nucleic acid oxidation.

@article{Grew2014DiurnalVO,
  title={Diurnal variation of urinary markers of nucleic acid oxidation.},
  author={Ida S Grew and Vanja Cejvanovic and Kasper Broedbaek and Trine N{\ae}ss Henriksen and Morten Petersen and Jon Tr{\ae}rup Andersen and Espen Jimenez-Solem and Allan Weimann and Henrik Enghusen Poulsen},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={2014},
  volume={74 4},
  pages={336-43}
}
AIMS Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) are biomarkers of oxidative stress with clinical potential in a variety of diseases. As part of their clinical validation, this study aimed to investigate whether the urinary excretion of 8-oxodG and 8-oxoGuo undergoes diurnal variation and to evaluate the validity of 6-hour sampling as well as creatinine corrected spot urine sampling. METHODS A total of 23 healthy study subjects collecting… CONTINUE READING

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