Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge.

@article{Lewis2010DiurnalVI,
  title={Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge.},
  author={Nia C S Lewis and Gisele Atkinson and Samuel John Edwin Lucas and Emily J M Grant and Helen Jones and Yu Chieh Tzeng and Helen M Horsman and Philip N. Ainslie},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={299 1},
  pages={
          R55-61
        }
}
Epidemiological data indicate that the risk of neurally mediated syncope is substantially higher in the morning. Syncope is precipitated by cerebral hypoperfusion, yet no chronobiological experiment has been undertaken to examine whether the major circulatory factors, which influence perfusion, show diurnal variation during a controlled orthostatic challenge. Therefore, we examined the diurnal variation in orthostatic tolerance and circulatory function measured at baseline and at presyncope. In… CONTINUE READING
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