Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women.

@article{Hassager1992DiurnalVI,
  title={Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women.},
  author={Christian Hassager and Juha P Risteli and Leila Risteli and Siri Beier Jensen and Claus Christiansen},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1992},
  volume={7 11},
  pages={
          1307-11
        }
}
There are several indications that the functions of human osteoblasts and osteoclasts have circadian rhythms with peak activities occurring at night. It is not known, however, whether the principal function of these cells, namely synthesis and degradation of the organic matrix of bone, of which about 90% is type I collagen, also has a circadian rhythm. This was therefore investigated for both the formation of type I collagen and the degradation of type I collagen in bone using two newly… CONTINUE READING
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