Diurnal variation and melatonin induction of hepatic molybdenum hydroxylase activity in the guinea-pig.

@article{Beedham1989DiurnalVA,
  title={Diurnal variation and melatonin induction of hepatic molybdenum hydroxylase activity in the guinea-pig.},
  author={Christine Beedham and D J Padwick and Y. Al-Tayib and Jayden A. Smith},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 9},
  pages={1459-64}
}
The activities of the xenobiotic metabolizing enzymes, aldehyde oxidase and xanthine oxidase, were determined in partially purified fractions of adult guinea-pig liver at given times in the day or night. A marked circadian variation in aldehyde oxidase activity was observed with several substrates (phthalazine, phenanthridine, N-phenylquinolinium and 3,4-dihydro-4-hydroxy-3-methyl-2-quinazolinone). The main peak occurred at 0300 hr with minimum activity from 1200 to 1800 hr, the differences… CONTINUE READING