Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography.

@article{Tavakkolizadeh2001DiurnalRI,
  title={Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography.},
  author={Ali Tavakkolizadeh and Urs V. Berger and K. Robert Shen and Lynne L. Levitsky and M. J. Zinner and Matthias A. Hediger and Stanley W Ashley and Edward E. Whang and David B. Rhoads},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={280 2},
  pages={G209-15}
}
Mechanisms underlying the circadian rhythmicity in intestinal sugar absorption remain unclear. To test whether this rhythmicity is caused by changes in Na(+)-glucose cotransporter 1 (SGLT-1) function, we measured phloridzin-inhibitable sugar fluxes as an index of SGLT-1 activity. Jejunum obtained from rats killed at 6-h intervals during a 12-h light-dark cycle (CT0 is circadian time 0 h, time of light onset) were mounted in Ussing chambers, and 3-O-methylglucose (3-OMG) fluxes were calculated… CONTINUE READING