Diurnal profiling of neuroendocrine genes in murine heart, and shift in proopiomelanocortin gene expression with pressure-overload cardiac hypertrophy.

@article{Chalmers2008DiurnalPO,
  title={Diurnal profiling of neuroendocrine genes in murine heart, and shift in proopiomelanocortin gene expression with pressure-overload cardiac hypertrophy.},
  author={Jennifer A. Chalmers and S J Lin and Tami A. Martino and S. Arab and Peter J Y Liu and Mansoor Husain and Michael Sole and Denise D. Belsham},
  journal={Journal of molecular endocrinology},
  year={2008},
  volume={41 3},
  pages={117-24}
}
Neuroendocrine peptides express biologic activity relevant to the cardiovascular system, including regulating heart rate and blood pressure, though little is known about the mechanisms involved. Here, we investigated neuroendocrine gene expression underlying diurnal physiology of the heart. We first used microarray and RT-PCR analysis and demonstrate the simultaneous expression of neuroendocrine genes in normal murine heart, including POMC, GnRH, neuropeptide Y, leptin receptor, GH-releasing… CONTINUE READING

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Circadian control of remodeling and structural genes in aortic smooth muscle in vivo and in vitro

  • JA Chalmers, TA Martino, N Tata, MR Ralph, MJ Sole, DD Belsham
  • Am J Physiol
  • 2008

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