Diurnal patterns of cocaine and heroin self-administration in rhesus monkeys responding under a schedule of multiple daily sessions.

@article{Negus1995DiurnalPO,
  title={Diurnal patterns of cocaine and heroin self-administration in rhesus monkeys responding under a schedule of multiple daily sessions.},
  author={S. Stevens Negus and N. K. Mello and S. E. Lukas and J S Mendelson},
  journal={Behavioural pharmacology},
  year={1995},
  volume={6 8},
  pages={763-775}
}
A number of non-pharmacological factors have been shown to influence drug self-administration in experimental animals. This report examines diurnal changes in drug self-administration by rhesus monkeys trained to self-administer food (1gm fruit-flavored pellets) and cocaine (0.01 or 0.032mg/kg/injection) under a second order FR4 (VR16:S) schedule during four daily food and drug self-administration sessions. Saline, different unit doses of cocaine (0.001-0.1mg/kg/injection) or different unit… CONTINUE READING

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