Diurnal fluctuations in free and total steady-state plasma levels of carbamazepine and correlation with intermittent side effects.

@article{Riva1984DiurnalFI,
  title={Diurnal fluctuations in free and total steady-state plasma levels of carbamazepine and correlation with intermittent side effects.},
  author={Roberto Riva and F. Medolago Albani and Giovanni Ambrosetto and Manuela Contin and Pietro Cortelli and Emilio Perucca and Agostino Baruzzi},
  journal={Epilepsia},
  year={1984},
  volume={25 4},
  pages={476-81}
}
The relationship between diurnal fluctuations in free (unbound) and total plasma carbamazepine levels and the appearance of intermittent side effects was investigated in nine epileptic patients receiving chronic therapy with carbamazepine, alone or in combination with phenobarbital. On a three-times-daily or four-times-daily dosing schedule, both total and free carbamazepine levels fluctuated considerably (on an average, 41 and 45%, respectively, around the mean). Side effects (particularly… CONTINUE READING