Diurnal‐Nocturnal Variations of Certain Blood Constituents in Normal Human Subjects: Plasma Iron, Siderophilin, Bilirubin, Copper, Total Serum Protein and Albumin, Haemoglobin and Haematocrit

@article{Stengle1957DiurnalNocturnalVO,
  title={Diurnal‐Nocturnal Variations of Certain Blood Constituents in Normal Human Subjects: Plasma Iron, Siderophilin, Bilirubin, Copper, Total Serum Protein and Albumin, Haemoglobin and Haematocrit},
  author={James M. Stengle and Arthur L. Schade},
  journal={British Journal of Haematology},
  year={1957},
  volume={3}
}
THE iron content and total iron-binding capacity of the plasma are subjects of wide scientific and medical interest. Evidence is accumulating that certain diseases have a characteristic effect not only on the concentration of plasma iron and its rate of turnover (Laurell, 1952; Brendstrup, 1953) but also on the concentration of the plasma iron-binding protein, siderophilin. Iron-deficiency anaemia, malignant neoplastic disease and acute and chronic infections, with the exception of viral… 
Transferrin Saturation: A Body Iron Biomarker.
Diurnal and nocturnal variations of the serum iron in normal subjects.
OBSERVATIONS ON THE PHYSIOLOGY OF ERYTHROPOIETIN AND ITS ROLE IN THE REGULATION OF RED CELL PRODUCTION
  • F. Stohlman
  • Medicine, Biology
    Annals of the New York Academy of Sciences
  • 1959
TLDR
It becomes of importance to determine the rate of formation and removal of erythropoietin from the plasma, the influence of the bone marrow and renal excretion on the plasma eryanthropoiet in clinical disorders, and the role of hypoxia and erythrooietIn in the response to posthemorrhagic anemia.
Association of serum iron and total iron binding capacity in rural children
TLDR
Iron deficiency and anemia appear to be an important public health problem among children and the effective actions aimed at the prevention and control of this deficiency are strongly recommended.
Postprandial zinc stable isotope response in human blood serum.
TLDR
The results indicate that studies examining solely the distribution of Zn isotopes in serum may obtain samples without considering timing of the most recent meal, and suggest that future studies seeking to compare serum Zn concentrations with δ66Zn values should draw blood samples in the morning after overnight fasting.
Hyperbilirubinemia of fasting.
TLDR
It was concluded that an increase in bilirubin concentration occurs as a function of fasting.
Studies of the production, volume and destruction of erythrocytes in patients with sarcoidosis.
TLDR
The purpose of this report is to present an investigation of the iron metabolism and apparent erythrocyte life span in patients with sarcoidosis.
DIURNAL VARIATION OF SERUM IRON IN INFANTS AND CHILDREN
TLDR
Evidence for the late appearance of a biological “clock” in children is supported by the evidence for the diurnal variation of serum iron found in healthy adults.
Diurnal variation in endogenous production of carbon monoxide. Effect of caloric restriction.
TLDR
It cannot be excluded that starvation affects erythropoiesis and/or red cell catabolism, thereby causing an increase in VCO and SB, and it is concluded that changes are secondary to a increase in total hemeCatabolism.
A Comparison of Three Simple, Rapid Methods for Red Blood Cell Removal from Whole Blood, Which are Suitable for Measuring Biomarkers at the Point of Care
TLDR
The method that used antibodies performed the best and could be integrated into a process whereby plasma markers are measured from a small volume of whole blood at the point-of-care.
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References

SHOWING 1-10 OF 18 REFERENCES
The diurnal variation of the serum iron concentration.
  • C. Laurell
  • Environmental Science, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 1953
TLDR
The diurnal variations of serum iron can be explained as a phenomenon secondary to the diurnal variation of the hemoglobin metabolism, supported by parallel changes in the bilirubin and serum iron values.
Observations on electrophoretic analysis of normal human serum.
The Aminco Model B electrophoresis apparatus was used; the quantitative results reported were derived exclusively from its interferometric optical system. Sera to be analyzed were obtained from
On Serum Copper. II. Technique of Analysis.
Summary. Description is given of the author's modification of Mcfarlane's Method for determination of the copper content of blood and serum by means of diethyl-dithiocarbamate. Experiments
The iron-binding capacity of serum in infants and children.
  • B. Hagberg
  • Medicine
    Acta paediatrica. Supplementum
  • 1953
Kupfir nnd Eisen als korpereigene Wirkstoffe, p
  • 66. Fischer, Jena. HEMMELER,
  • 1941
Bound Iron and Unsaturated Iron-binding Capacity of Serum; Rapid and Reliable Quantitative Determination
TLDR
The proposed method for determination of iron-free siderophilin, or unsaturated iron-binding capacity of serum (UIBC), involves addition to serum of iron in excess of that capable of being bound, followed by direct analysis of serum sample with terpyridine as the chromogenic agent without acidification or the removal of constituent proteins.
Plasma iron and the transport of iron in the organism.
  • C. Laurell
  • Chemistry, Medicine
    Pharmacological reviews
  • 1952
...
...