Diuretics stimulate H+ secretion in turtle urinary bladder.

  title={Diuretics stimulate H+ secretion in turtle urinary bladder.},
  author={P. D. Lief and Bernd Mutz and Nederlandsche Bank},
  journal={The Journal of clinical investigation},
  volume={65 5},
The effect of various diuretics on H+ secretion was studied in the isolated short-circuited urinary bladder of the turtle. Mucosal (urinary) chlorothiazide stimulated H+ secretion promptly, from 1.33 +/- 0.24 to 3.03 +/- 0.25 mueq/h (P less than 0.001). The effect was rapidly reversible upon washout of the drug, H+ returning to control levels, 1.37 +/- 0.26 mueq/h (P less than 0.001). Similar effects were observed with mucosal hydrochlorothiazide and mucosal ethacrynic acid/cysteine… CONTINUE READING