Diuretic effect and metabolism of bumetanide in man.

  title={Diuretic effect and metabolism of bumetanide in man.},
  author={S C Halladay and I. Glenn Sipes and Dean Edwin Carter},
  journal={Clinical pharmacology and therapeutics},
  volume={22 2},
Bumetanide (3-N-butylamino-4-phenoxy-5-sulfamyl-benzoic acid) is a sulfonamide congener with potent diuretic activity in man. Oral administration of 14C-bumetanide (2 mg, 22 71Ci) to 4 adult male volunteers was rapidly and almost completely absorbed (greater than 95%). Its average apparent volume of distribution was 25 L. Bumetanide induced a ceiling diuresis at 1 hr, with loss of Na+ and water for 4 to 5 hr. Loss of K+ was minimal. Bumetanide was quickly eliminated by metabolism and urinary… CONTINUE READING
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