Diuretic action of the narcotic antagonist oxilorphan

@article{Nutt1974DiureticAO,
  title={Diuretic action of the narcotic antagonist oxilorphan},
  author={J. F. Nutt and D. Jasinski},
  journal={Clinical Pharmacology & Therapeutics},
  year={1974},
  volume={15}
}
  • J. F. Nutt, D. Jasinski
  • Published 1974
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • The narcotic antagonists oXilorphan and d,l‐cyclazocine increased urinary output without affecting fluid intake in 10 subjects on ad libitum fluids. 1n 8 water‐deprived subjects oXilorphan increased urinary output and decreased urine osmolality without significantly altering blood pressure, creatinine clearance, electrolyte excretion, or solute excretion. Three of 4 water‐loaded subjects excreted a water load slightly more efficiently after the drug. Ten milligrams of naloxone had no diuretic… CONTINUE READING
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