Dithranol Embedded in Crystalline Monoglycerides Combined with Phototherapy (UVB): A New Approach in the Treatment of Psoriasis

@article{Gerritsen1998DithranolEI,
  title={Dithranol Embedded in Crystalline Monoglycerides Combined with Phototherapy (UVB): A New Approach in the Treatment of Psoriasis},
  author={M. Gerritsen and J. Boezeman and M. Elbers and P. V. D. van de Kerkhof},
  journal={Skin Pharmacology and Physiology},
  year={1998},
  volume={11},
  pages={133 - 139}
}
Treatment of psoriasis with dithranol as monotherapy or dithranol in combination with UVB phototherapy is an effective and safe approach for the management of psoriasis. Recently a new formulation of dithranol embedded in crystalline monoglycerides (Micanol) has become available. It was shown that this formulation combines adequate efficacy with low irritation and staining properties. The aim of the present study was to compare and contrast three treatment schedules with respect to clinical… Expand
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References

SHOWING 1-10 OF 10 REFERENCES
Clinical response and side-effects in the treatment of psoriasis with UV-B and -A novel dithranol formulation.
TLDR
It is suggested that this novel formulation in which the dithranol is microencapsulated by crystalline monoglycerides may become an important contribution to the management of psoriasis. Expand
Effect of UVB therapy and a coal tar bath on short contact dithranol treatment for psoriasis
TLDR
It is shown that UVB therapy does not improve the clearance of psoriasis in SCDT, but does significantly postpone relapse, and comparison of pre‐ and post‐treatment full blood count, biochemical screen and urinalysis showed no evidence of systemic toxicity due to SCDT. Expand
[Combined 1-hour therapy of psoriasis using anthralin and UV light].
  • S. Schauder, G. Mahrle
  • Medicine
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 1982
TLDR
The results show that the 1-h treatment with 1% anthralin seems to be advantageous especially for the treatment of out-patients with circumscribed chronic psoriatic lesions, and UV-light did not improve considerably the therapeutic effect of Anthralin in the regimen of this study. Expand
Effect of short-contact anthralin therapy on ultraviolet B irradiation of psoriasis.
The influence of short-contact anthralin on the therapeutic effect of ultraviolet B irradiation (Sylvania UV-21 tubes) was investigated with the half-body comparison method in fifteen outpatientsExpand
Short contact anthralin therapy of psoriasis with and without UV-irradiation and maintenance schedule to prevent relapses.
A short term anthralin application schedule was used at home in 42 patients with severe psoriasis. In another group of 21 patients treated at our day care center, UV-B irradiation was added when theExpand
Narrow-band UVB (311 nm) versus conventional broad-band UVB with and without dithranol in phototherapy for psoriasis.
TLDR
The therapeutic efficacy of the Philips TL 01 in a new 100 W version and its practicability for psoriasis phototherapy have been demonstrated. Expand
Clearing of resistant psoriasis with anthralin.
TLDR
Treatment of 22 resistant psoriatics with a modification of the Ingram regimen revealed early rapid flattening of plaques and a significant reduction in total time required for clearing when compared to responses of previous conventional therapy. Expand
Embedding of dithranol in lipid crystals.
  • Å. Lindahl
  • Medicine
  • Acta dermato-venereologica. Supplementum
  • 1992
TLDR
A new cream base, based on lipid crystals, was used to formulate an antipsoriatic cream containing Dithranol, which is easy to wash off, provides good stability of dithanol, and is practically nonstaining. Expand
Kombinierte Einstundentherapie der Psoriasis mit Anthralin and UV-Licht
  • Hautarzt
  • 1982
Über Cignolin, ein Ersatzpräparat des Chrysarobins
  • Dermatol Wochenschr
  • 1916