Dithranol Embedded in Crystalline Monoglycerides Combined with Phototherapy (UVB): A New Approach in the Treatment of Psoriasis

  title={Dithranol Embedded in Crystalline Monoglycerides Combined with Phototherapy (UVB): A New Approach in the Treatment of Psoriasis},
  author={M. Gerritsen and J. Boezeman and M. Elbers and P. V. D. van de Kerkhof},
  journal={Skin Pharmacology and Physiology},
  pages={133 - 139}
Treatment of psoriasis with dithranol as monotherapy or dithranol in combination with UVB phototherapy is an effective and safe approach for the management of psoriasis. Recently a new formulation of dithranol embedded in crystalline monoglycerides (Micanol) has become available. It was shown that this formulation combines adequate efficacy with low irritation and staining properties. The aim of the present study was to compare and contrast three treatment schedules with respect to clinical… Expand
Combination phototherapy of psoriasis with narrow-band UVB irradiation and topical tazarotene gel.
The addition of tazarotene to narrow-band UVB phototherapy promotes more effective, faster clearing of psoriasis compared with UVB (311 nm) monotherapy. Expand
Standard and innovative therapy of psoriasis.
There is no cure for psoriasis, a variety of therapeutic modalities is available to reduce the severity and increase the life quality of the patient, and a risk-benefit ratio must be taken into account. Expand
Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol.
The in vitro permeation study using mouse abdominal skin shows significantly enhanced permeation with vesicles as indicated by flux of dithranol from liposomes and niosomes as compared with the cream base. Expand
Topical Agents for the Treatment of Psoriasis, Past, Present and Future
A brief review of the major single topical therapies for psoriasis, as well as combination therapy, is focused on. Expand
Topical treatment of psoriasis.
Proper patient education about the disease, the treatment options, their specific application modality and adverse effects is essential to ensure therapeutic success, and will help alleviate the common problem of poor patient adherence, and inevitably result in more optimal clinical outcomes. Expand
Combination therapy in the treatment of psoriasis
  • S. Domm, U. Mrowietz
  • Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2011
Current knowledge about the use of combination therapies in psoriasis is summarized on the basis of published literature in the form of a table to show which combinations are possible, useful or which can not be recommended. Expand
Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients
To enhance anthralin efficacy against psoriasis and reduce its notorious side effects, it was loaded into various liposomal and ethosomal preparations. The nanocarriers were characterized for drugExpand
S3 – Guidelines on the treatment of psoriasis vulgaris (English version). Update
  • A. Nast, W. Boehncke, +19 authors B. Rzany
  • Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2012
The Guidelines focus on induction therapy in cases of mild, moderate and severe plaque‐type psoriasis in adults including systemic therapy, UV therapy and topical therapies. Expand
German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version)
The short version of the guidelines reported here consist of a series of therapeutic recommendations that are based on a systematic literature search and subsequent discussion with experts in the field and have been approved by a team of dermatology experts. Expand
A variety of biochemical and molecular biological alterations have been identified, but the pathogenesis of psoriasis is still not clear and innovative therapeutical strategies have been developed recently. Expand


Clinical response and side-effects in the treatment of psoriasis with UV-B and -A novel dithranol formulation.
It is suggested that this novel formulation in which the dithranol is microencapsulated by crystalline monoglycerides may become an important contribution to the management of psoriasis. Expand
Effect of UVB therapy and a coal tar bath on short contact dithranol treatment for psoriasis
It is shown that UVB therapy does not improve the clearance of psoriasis in SCDT, but does significantly postpone relapse, and comparison of pre‐ and post‐treatment full blood count, biochemical screen and urinalysis showed no evidence of systemic toxicity due to SCDT. Expand
[Combined 1-hour therapy of psoriasis using anthralin and UV light].
  • S. Schauder, G. Mahrle
  • Medicine
  • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 1982
The results show that the 1-h treatment with 1% anthralin seems to be advantageous especially for the treatment of out-patients with circumscribed chronic psoriatic lesions, and UV-light did not improve considerably the therapeutic effect of Anthralin in the regimen of this study. Expand
Effect of short-contact anthralin therapy on ultraviolet B irradiation of psoriasis.
The influence of short-contact anthralin on the therapeutic effect of ultraviolet B irradiation (Sylvania UV-21 tubes) was investigated with the half-body comparison method in fifteen outpatientsExpand
Short contact anthralin therapy of psoriasis with and without UV-irradiation and maintenance schedule to prevent relapses.
A short term anthralin application schedule was used at home in 42 patients with severe psoriasis. In another group of 21 patients treated at our day care center, UV-B irradiation was added when theExpand
Narrow-band UVB (311 nm) versus conventional broad-band UVB with and without dithranol in phototherapy for psoriasis.
The therapeutic efficacy of the Philips TL 01 in a new 100 W version and its practicability for psoriasis phototherapy have been demonstrated. Expand
Clearing of resistant psoriasis with anthralin.
Treatment of 22 resistant psoriatics with a modification of the Ingram regimen revealed early rapid flattening of plaques and a significant reduction in total time required for clearing when compared to responses of previous conventional therapy. Expand
Embedding of dithranol in lipid crystals.
  • Å. Lindahl
  • Medicine
  • Acta dermato-venereologica. Supplementum
  • 1992
A new cream base, based on lipid crystals, was used to formulate an antipsoriatic cream containing Dithranol, which is easy to wash off, provides good stability of dithanol, and is practically nonstaining. Expand
Kombinierte Einstundentherapie der Psoriasis mit Anthralin and UV-Licht
  • Hautarzt
  • 1982
Über Cignolin, ein Ersatzpräparat des Chrysarobins
  • Dermatol Wochenschr
  • 1916