Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance.

@article{Liang2018DithiothreitolRegulatedCO,
  title={Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance.},
  author={Pingping Liang and Juan Canoura and Haixiang Yu and Obtin Alkhamis and Yi Xiao},
  journal={ACS applied materials & interfaces},
  year={2018},
  volume={10 4},
  pages={
          4233-4242
        }
}
DNA-modified gold nanoparticles (AuNPs) are useful signal-reporters for detecting diverse molecules through various hybridization- and enzyme-based assays. However, their performance is heavily dependent on the probe DNA surface coverage, which can influence both target binding and enzymatic processing of the bound probes. Current methods used to adjust the… CONTINUE READING