Dithiol Antagonism and Potentiation of Chemotherapeutic Agents

  title={Dithiol Antagonism and Potentiation of Chemotherapeutic Agents},
  author={N. Ercoli and B. Gosford and Giovanni Maria Carminati and D. Kley and B. Schwartz},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={253 - 261}
  • N. Ercoli, B. Gosford, +2 authors B. Schwartz
  • Published 1951
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
  • Summary and Conclusions (1) In experimental spirochetal infections BAL reverses the therapeutic activity of penicillin, bacitracin, Chloromycetin, oxophenarsine and gold compounds (Myochrysin), while it has no influence on streptomycin, terramycin and aureomycin. (In most cases subtilin has not been affected, occasionally it has been potentiated by BAL and by cysteine). (2) Monothiols (cysteine and glutathione) do not induce the reversal obtained with BAL. (3) In trypanosomal infection BAL… CONTINUE READING
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