Dithiobiuret neurotoxicity: an ultrastructural investigation of the lesion in preterminal axons and motor endplates in the rat lumbrical muscle

@article{Jones1989DithiobiuretNA,
  title={Dithiobiuret neurotoxicity: an ultrastructural investigation of the lesion in preterminal axons and motor endplates in the rat lumbrical muscle},
  author={Huw B. Jones},
  journal={Acta Neuropathologica},
  year={1989},
  volume={78},
  pages={72-85}
}
2,4-Dithiobiuret was given i.p. to rats for 4 days at a daily dosage of 1 mg/kg and the development of the lesion associated with neuromuscular dysfunction studied in hindlimb lumbrical muscles. The first morphological indication of neurointoxication was the appearance in some motor endplates of masses of branching tubular smooth endoplasmic reticulum (SER) on day 2 which correlated with the initial functional disturbances. By the 3rd day, most motor endplates were distended by accumulations of… CONTINUE READING

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References

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Showing 1-10 of 46 references

Immunohistochemical localisation of cytochrome P450 in rat brain

  • J Kapitulnik, HV Gelboin, FP Guengeric, DM Jacobowitz
  • Neuroscience
  • 1987
1 Excerpt

Subcellular distribution ofcytochrome P-450 in the brain

  • B Walther, JF Ghersi-Eggea, A Minn, G Siest
  • Brain Res
  • 1986
1 Excerpt

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