Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells

@article{Morhmann2004Dithiobismercaptoethanesulphonate,
  title={Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells},
  author={Matthias Morhmann and Stefan Ansorge and B. Sch{\"o}nfeld and Matthias Brandis},
  journal={Pediatric Nephrology},
  year={2004},
  volume={8},
  pages={458-465}
}
Ifosfamide (IF) is an alkylating cytostatic with urotoxic (haemorrhagic cystitis) and nephrotoxic (Fanconi syndrome) side effects. Cyclophosphamide (CP), a structural isomer of IF, shows urotoxic but no nephrotoxic side effects. The development of haemorrhagic cystitis during therapy with IF or CP can be prevented by the uroprotective drug sodium-2-mercaptoethanesulphonate (MESNA). However, even in the presence of MESNA, Fanconi syndrome may still develop after therapy with IF. Using the renal… 
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  • Medicine
    Medical and pediatric oncology
  • 2003
TLDR
It is concluded that considerable nephrotoxicity is still present 10 years after completion of ifosfamide treatment, but that the outcome varies between individual patients, suggesting an urgent need for the development and clinical investigation of nephroprotective strategies.
Acrolein scavengers: reactivity, mechanism and impact on health.
TLDR
A comprehensive understanding of the mechanism involved in the application of reactive scavengers to directly trap ACR may help to establish ACR scavenging as a novel therapeutic intervention against human diseases associated with ACR and/or oxidative stress.
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TLDR
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Clinicians should be vigilant for its development, as timely intervention may minimise complications, and patients should be monitored for development of renal tubular dysfunction and osteodystrophy.
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