Diterpenoids from Haplopappus rigidus.

@article{Morales2000DiterpenoidsFH,
  title={Diterpenoids from Haplopappus rigidus.},
  author={G. E. Leyte Morales and Pilar Sierra and Luis Alberto Loyola and Jorge B{\'o}rquez},
  journal={Phytochemistry},
  year={2000},
  volume={55 8},
  pages={863-6}
}
Fractionation of the aerial parts of Haplopappus rigidus Phil., directed by the brine shrimp lethality test (BST), has led to the isolation of two new diterpenoids, rigidusol and deacetylrigidusol. Their structures were established as 13-hydroxy-18-acetoxy-cis-cleroda-3,14-diene (8betaH, 10betaH, 19beta, 20alpha form) and 13,18-dihydroxy-cis-cleroda-3,14-diene (8betaH, 10betaH, 19beta, 20alpha form), respectively. Rigidusol exhibit moderate cytotoxic activity against human breast adenocarcinoma… CONTINUE READING

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