Diterpenoid alkaloids from Delphinium gracile

  title={Diterpenoid alkaloids from Delphinium gracile},
  author={Mat{\'i}as Reina and R Mancha and Azucena Gonz{\'a}lez-Coloma and Mar{\'i}a Bail{\'e}n and M L Rodr{\'i}guez and Rafael Mart{\'i}nez-D{\'i}az},
  journal={Natural Product Research},
  pages={1048 - 1055}
Two highly oxygenated hetisine-type diterpenoid alkaloids, delphigraciline (1), 14-hydroxyhetisinone N-oxide (2), and the norditerpenoid alkaloid 8-methoxykarakoline (3), were isolated from a neutral extract of Delphinium gracile. Their structures were elucidated on the basis of spectroscopic data and by comparison with previously reported spectroscopic data of similar alkaloids. Their antiparasitic and insecticidal activities are also discussed. 
Diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum with their antifeedant activity on Spodoptera exigua
A new lycoctonine diterpenoid alkaloid navicularine was isolated from the whole plant of Delphinium naviculare var.
An overview of the chemical constituents from the genus Delphinium reported in the last four decades
This review addresses, for the first time, the chemical constituents of Delphinium plants and the biological properties of these compounds to facilitate future research.
Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua.
Twenty-five diterpenoid alkaloids were isolated from the roots of two Aconitum species and chasmanthinine (19) showed highly potent antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 0.07 mg/cm2.
Chemistry and biological activities of hetisine-type diterpenoid alkaloids
Parmacological studies have revealed a wide range of pharmacological actions for hetisine-type DAs, including antiarrhythmic, antitumor, antimicrobial and insecticidal activities, as well as effects on peripheral vasculature, which are closely related to their chemical structures.
Review of Compounds and Pharmacological Effects of Delphinium
Plants of Delphinium are herbal medicine used in the Tibet region with whole grass as a drug, which have the effects of analgesic, antibacterial, antipyretic, and anticancer. The main bioactive
Structural diversity and defensive properties of diterpenoid alkaloids
Overall, C19 norditerpenoid alkaloids (NDAs) resulted better insect antifeedants and post-ingestive toxicants than the related C20 diterpene alkaloid (DAs), while DAs had strong antiparasitic effects with molecular selectivity while NDAs were inactive.
The C19-diterpenoid alkaloids.
Acylated flavonol tetraglycosides from Delphinium gracile.


Hetisane - Type Diterpenoid Alkaloids
Data in the literature up to 1998 on hetisane-type diterpenoid alkaloids isolated from plants of the generaAconitum, Consolida, Delphinium, Thalictrum,andSpireaare reviewed and systematized. Data on
Four new alkaloids from Consolida glandulosa.
Four new hetisine-type diterpenoids, isolated from Consolida glandulosa, were determined by two-dimensional NMR techniques and substantiated by a single-crystal X-ray analysis performed on compound 3.
Antifeedant C20 Diterpene Alkaloids
The results support the plant protective role of C20 diterpenoid alkaloids and open a new field for parasite control strategies, as well as supporting the antifeedant effects of test compounds, which were structure‐ and species‐dependent.
Structural Diversity and Defensive Properties of Norditerpenoid Alkaloids
The selective cytotoxic effects of some structures indicate that they can act on biological targets other than neuroreceptors in Spodoptera littoralis and Leptinotarsa decemlineata.
Defensive chemistry of Senecio miser.
Eremophilanolides 1 and 2 and alkaloids 4 and 5 were found to be strong insect antifeedants, further supporting a proposed defensive role for these classes of compounds.
Selective Action of Acetogenin Mitochondrial Complex I Inhibitors
The in vivo effects of these compounds on S. littoralis and their cytotoxic effects on Sf9 and tumor cells were more predictable than their effect on T. cruzi and mammalian cells.