Diterpenes from Xylopia langsdorffiana inhibit cell growth and induce differentiation in human leukemia cells.

@article{Branco2009DiterpenesFX,
  title={Diterpenes from Xylopia langsdorffiana inhibit cell growth and induce differentiation in human leukemia cells.},
  author={Marianna Vieira Sobral Castello Branco and Maristella Conte Anazetti and Marcelo Sobral da Silva and Josean Fechine Tavares and Margareth F. F. Melo Diniz and Lucas Frungillo and Marcela Haun and Patr{\'i}cia da Silva Melo},
  journal={Zeitschrift fur Naturforschung. C, Journal of biosciences},
  year={2009},
  volume={64 9-10},
  pages={650-6}
}
Two new diterpenes were isolated from stems and leaves of Xylopia langsdorffiana, ent-atisane-7alpha,16alpha-diol (xylodiol) and ent-7alpha-acetoxytrachyloban-18-oic acid (trachylobane), along with the known 8(17),12E,14-labdatrien-18-oic acid (labdane). We investigated their antitumour effects on HL60, U937 and K562 human leukemia cell lines. We found that xylodiol was the most potent diterpene in inhibiting cell proliferation of HL60, U937 and K562 cells, with mean IC50 values of 90, 80 and… CONTINUE READING

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