Disuse and orchidectomy have additional effects on bone loss in the aged male rat

@article{Blouin2006DisuseAO,
  title={Disuse and orchidectomy have additional effects on bone loss in the aged male rat},
  author={St{\'e}phane Blouin and Yves Gallois and Marie Françoise Moreau and M. F. Basl{\'e} and Daniel Chappard},
  journal={Osteoporosis International},
  year={2006},
  volume={18},
  pages={85-92}
}
A severely osteopenic rat model was obtained by combining orchidectomy (ORX) and disuse (due to local paralysis induced by botulinum toxin [BTX] in the quadriceps muscle). Forty-two aged male rats (5–6 months old) were randomized into three groups: 18 were SHAM operated; 6 were ORX; and 18 were ORX and BTX injected in the right hindlimb. One, two, and three months after surgery, bone mass (BV/TV) and microarchitectural parameters (Tb.Th, Tb.N, Tb.Sp, Tb.Pf, and structure model index [SMI]) were… CONTINUE READING