Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer.

@article{Kim2016DisulfiramTC,
  title={Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer.},
  author={Ji Young Kim and Youngkwan Cho and Jae Hong Seo and Nahyun Lee and Hyunsook An and Daeil Sung and Tae-Min Cho},
  journal={Cancer letters},
  year={2016},
  volume={379 1},
  pages={39-48}
}
HER2-positive breast tumors are known to harbor cancer stem-like cell populations and are associated with an aggressive tumor phenotype and poor clinical outcomes. Disulfiram (DSF), an anti-alcoholism drug, is known to elicit cytotoxicity in many cancer cell types in the presence of copper (Cu). The objective of the present study was to investigate the mechanism of action responsible for the induction of apoptosis by DSF/Cu and its effect on cancer stem cell properties in HER2-positive breast… CONTINUE READING
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