Disulfiram‐Cotrimoxazole Reaction

  title={Disulfiram‐Cotrimoxazole Reaction},
  author={Mark Heelon and M. White},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  • M. Heelon, M. White
  • Published 8 July 1998
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
The disulfiram‐ethanol reaction is a well‐known clinical phenomenon occurring as a result of acetaldehyde accumulation in the blood. Symptoms usually begin within 5–15 minutes after ingestion of ethanol in patients who have taken disulfiram 3–123 hours earlier, and generally occur in the following order: flushing, sweating, palpitations, dyspnea, hyperventilation, increased pulse rate, fall in blood pressure, nausea, vomiting, and drowsiness. Patients need not experience all these symptoms, and… 
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