Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines.

@article{Guo2010DisulfiramcopperCI,
  title={Disulfiram/copper complex inhibiting NFkappaB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines.},
  author={Xiaoxia Guo and Bin Xu and Shuchita Pandey and Elisabeth Goessl and James Brown and Angel Luis Armesilla and John L. Darling and Weiguang Wang},
  journal={Cancer letters},
  year={2010},
  volume={290 1},
  pages={104-13}
}
Most of the gemcitabine (dFdC) resistant cell lines manifested high NFkappaB activity. The NFkappaB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFkappaB inhibitor, and copper (Cu) on the chemoresistant cell lines was examined. The DS/Cu complex significantly enhanced the cytotoxicity of dFdC (resistant cells: 12.2-1085-fold) and completely reversed the dFdC resistance in the resitant cell lines. The dFdC-induced… CONTINUE READING

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