Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro.

@article{Hober1997DisulfideEF,
  title={Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro.},
  author={Sophia Hober and Mathias Uhl{\'e}n and B. -A. Nilsson},
  journal={Biochemistry},
  year={1997},
  volume={36 15},
  pages={4616-22}
}
We have previously concluded that insulin-like growth factor-I (IGF-I) is thermodynamically unable to quantitatively form its disulfide bonds under reversible redox conditions in vitro. From detailed analyses it was hypothesized that the 47-52 disulfide is energetically unfavorable in the native IGF-I structure [Hober et al. (1992) Biochemistry 31, 1749… CONTINUE READING