Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost.

@article{Liu2012DisulfideCL,
  title={Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost.},
  author={Hongmei Liu and Hui Wang and Wenjun Yang and Yiyun Cheng},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 42},
  pages={17680-7}
}
Cationic poly(amidoamine) (PAMAM) dendrimers were widely used as nonviral gene carriers. PAMAM dendrimer-based products such as Superfect and Priofect were already commercially available gene transfection reagents. However, these products are based on high generation dendrimers with high cost and serious cytotoxicity. In this study, we prepared high efficient gene carriers using disulfide cross-linked low generation (generation 2, G2) PAMAM dendrimers. These synthesized materials can… CONTINUE READING
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