Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery.

@article{Dong2015DisulfidebridgedCP,
  title={Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery.},
  author={Haiqing Dong and Min Tang and Yan Li and Yongyong Li and Dong Qian and Donglu Shi},
  journal={Nanomedicine},
  year={2015},
  volume={10 12},
  pages={
          1941-58
        }
}
PEGylation in polymeric nanomedicine has gained substantial predominance in biomedical applications due to its resistance to protein absorption, which is critically important for a therapeutic delivery system in blood circulation. The shielding layer of PEGylation, however, creates significant steric hindrance that negatively impacts cellular uptake and intracellular distribution at the target site. This unexpected effect compromises the biological efficacy of the encapsulated payload. To… 

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