Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

@article{Sztolsztener2013DisulfideBF,
  title={Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.},
  author={Malgorzata Eliza Sztolsztener and Anita Brewinska and Bernard Guiard and Agnieszka Chacinska},
  journal={Traffic},
  year={2013},
  volume={14 3},
  pages={309-20}
}
The conserved MIA pathway is responsible for the import and oxidative folding of proteins destined for the intermembrane space of mitochondria. In contrast to a wealth of information obtained from studies with yeast, the function of the MIA pathway in higher eukaryotes has remained enigmatic. Here, we took advantage of the molecular understanding of the MIA pathway in yeast and designed a model of the human MIA pathway. The yeast model for MIA consists of two critical components, the disulfide… CONTINUE READING
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