Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium.

@article{Fernndez2004DisturbingES,
  title={Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium.},
  author={E. L{\'o}pez-Anglada Fern{\'a}ndez and Camilla Svenson and Lennart Dencker and A. K. Gustafson},
  journal={Reproductive toxicology},
  year={2004},
  volume={18 5},
  pages={653-60}
}
Cadmium accumulation in the mouse gut endoderm occurs until the closure of the vitelline duct (day 9 post-coitus; p.c.), producing anterior neural tube defects (NTD). The anterior part of the primitive endoderm, designated as the primary signaling center for anterior patterning, expresses several transcription factors of importance for head formation. Here, we studied the expression levels of some of these transcription factors (Hesx1, HNF3beta, Cerl, Otx2 and Sox2), and cell death induced… CONTINUE READING

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