Disturbed pyloric motility in Ws/Ws mutant rats due to deficiency of c-kit-expressing interstitial cells of Cajal.

@article{Nakama1998DisturbedPM,
  title={Disturbed pyloric motility in Ws/Ws mutant rats due to deficiency of c-kit-expressing interstitial cells of Cajal.},
  author={Akihiro Nakama and Seiichi Hirota and T Okazaki and Kouichi Nagano and Sunao Kawano and Masatsugu Hori and Yukisato Kitamura},
  journal={Pathology international},
  year={1998},
  volume={48 11},
  pages={843-9}
}
Interstitial cells of Cajal (ICC) are believed to initiate the basic contractile activity of the gastrointestinal tract. Interstitial cells of Cajal express c-kit receptor tyrosine kinase and are deficient in Ws/Ws mutant rats with a small deletion of the c-kit gene. As Ws/Ws rats show remarkable bile reflux to the stomach, the contraction pressure of the pylorus was compared between Ws/Ws and control +/+ rats. The contraction pressure of the pylorus was measured using a microtransducer, which… CONTINUE READING

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