Disturbed flow promotes deposition of leucocytes from flowing whole blood in a model of a damaged vessel wall.

@article{Skilbeck2004DisturbedFP,
  title={Disturbed flow promotes deposition of leucocytes from flowing whole blood in a model of a damaged vessel wall.},
  author={Christopher A. Skilbeck and Peter G. Walker and T. Leutenegger David and Gerard B Nash},
  journal={British journal of haematology},
  year={2004},
  volume={126 3},
  pages={418-27}
}
Departure from simple laminar flow in arteries may promote the local attachment of leucocytes either to intact endothelium or platelet thrombi. We perfused blood through a chamber with a backward facing step, to observe whether adhesion from whole blood to P-selectin was indeed localized to a region of recirculating flow, and whether platelets binding to collagen in such a region could capture leucocytes. Blood flowing over the step established a stable vortex, a reattachment point where… CONTINUE READING

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