Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex.

@article{Igarashi2011DisturbedCP,
  title={Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex.},
  author={Miki Igarashi and Kaizong Ma and Fei Gao and Hyungwook Kim and Stanley I. Rapoport and Jagadeesh Sridhara Rao},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={24 3},
  pages={507-17}
}
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by brain deposition of senile (neuritic) plaques containing amyloid-β, neurofibrillary tangles, synaptic loss, neuroinflammation, and overexpression of arachidonic acid (AA, 20:4n-6) metabolizing enzymes. Lipid concentration changes have been reported in different brain regions, but often partially or as a percent of the total concentration. In this study, we measured absolute concentrations (per gram wet weight… CONTINUE READING