Disturbed blood flow acutely induces activation and apoptosis of the human vascular endothelium.

@article{Jenkins2013DisturbedBF,
  title={Disturbed blood flow acutely induces activation and apoptosis of the human vascular endothelium.},
  author={Nathan T Jenkins and J. P. Torres Padilla and Leryn J. Boyle and Daniel P Credeur and Maurice Harold Laughlin and Paul J Fadel},
  journal={Hypertension},
  year={2013},
  volume={61 3},
  pages={615-21}
}
There is strong and consistent evidence from in vitro studies that disturbed blood flow produces a proatherogenic vascular endothelial phenotype. However, data from human studies are lacking. To address this, a 220 mm Hg occlusion cuff was placed on the distal forearm of 10 young, healthy men to induce a localized region of disturbed blood flow in the proximal vasculature for 20 minutes. We hypothesized that disturbed blood flow would induce endothelial activation and apoptosis as indicated by… CONTINUE READING
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