Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.

@article{Katayama2001DisturbedAO,
  title={Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.},
  author={Taiichi Katayama and Kazunori Imaizumi and Arata Honda and Toshi Yoneda and Takashi Kudo and Masatoshi Takeda and Kazutoshi Mori and Richard F. Rozmahel and Paul Fraser and Peter H. St George-Hyslop and Masaya Tohyama},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 46},
  pages={43446-54}
}
Recent studies have shown independently that presenilin-1 (PS1) null mutants and familial Alzheimer's disease (FAD)-linked mutants should both down-regulate signaling of the unfolded protein response (UPR). However, it is difficult to accept that both mutants possess the same effects on the UPR. Furthermore, contrary to these observations, neither loss of PS1 and PS2 function nor expression of FAD-linked PS1 mutants were reported to have a discernable impact on the UPR. Therefore, re… CONTINUE READING
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