Disturbed Th1 and Th2 balance in patients with Graves' disease.

  title={Disturbed Th1 and Th2 balance in patients with Graves' disease.},
  author={Yeganeh Eshaghkhani and Mohammad Sanati and Manouchehr Nakhjavani and Reza Safari and A. Hamid Khajavi and Mitra Ataei and Zohreh Jadali},
  journal={Minerva endocrinologica},
  volume={41 1},
BACKGROUND AND METHODS Graves' disease (GD) is a common autoimmune disorder that is primarily driven by malfunction of T lymphocytes, which influences the production of antibodies reacting with cellular and tissue components of the thyroid gland. The aim of this study was to determine the level of mRNA expression for the genes encoding T-bet and GATA3, as the master regulators of the T helper (Th)1 and Th2 differentiation, respectively together with Th1 (IFN-γ) and Th2(IL-4) cytokine mRNA… CONTINUE READING