Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease

@inproceedings{Hussain2017DisturbedMM,
  title={Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease },
  author={Ali Aijaz Hussain and Yunhee Lee and Jin-Jun Zhang and Paul T Francis and John Marshall},
  booktitle={Journal of neurodegenerative diseases},
  year={2017}
}
Purpose. Abnormal protein deposits including β-amyloid, found in ageing Bruch's membrane and brain, are susceptible to degradation by matrix metalloproteinases (MMPs). In ageing Bruch's membrane, these MMPs become less effective due to polymerisation and aggregation reactions (constituting the MMP Pathway), a situation much advanced in age-related macular degeneration (AMD). The likely presence of this MMP Pathway in brain with the potential to compromise the degradation of β-amyloid associated… CONTINUE READING
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