Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.

@article{Benesic2005DisturbedCB,
  title={Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.},
  author={Andreas Benesic and Gerald Schwerdt and Sigrid Mildenberger and Ruth Freudinger and Nader Gordjani and Michael Gekle},
  journal={Kidney international},
  year={2005},
  volume={68 5},
  pages={2029-41}
}
BACKGROUND Renal damage following chemotherapy with ifosfamide is attributed to the metabolic activation of the drug and the generation of chloroacetaldehyde (CAA). Little is known about the mechanism by which CAA impairs renal function. In this study the effect of CAA on intracellular Ca(2+) homeostasis in human renal proximal tubule cells (RPTEC) in… CONTINUE READING