Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer’s Disease In Vitro

@inproceedings{Kimpe2012DisturbedCH,
  title={Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer’s Disease In Vitro},
  author={Line De Kimpe and Anna Bennis and Rob Zwart and Elise S. van Haastert and Jeroen J. M. Hoozemans and Wiep Scheper},
  booktitle={PloS one},
  year={2012}
}
A major neuropathological hallmark of Alzheimer's disease (AD) is the deposition of aggregated β amyloid (Aβ) peptide in the senile plaques. Aβ is a peptide of 38-43 amino acids and its accumulation and aggregation plays a key role early in the disease. A large fraction of β amyloid is N-terminally truncated rendering a glutamine that can subsequently be… CONTINUE READING