Disturbances of Menstruation in Thyroid Disease

  title={Disturbances of Menstruation in Thyroid Disease},
  author={Demetrios A. Koutras},
  journal={Annals of the New York Academy of Sciences},
  • D. Koutras
  • Published 1 June 1997
  • Medicine, Biology
  • Annals of the New York Academy of Sciences
Both hyper- and hypothyroidism may result in menstrual disturbances. In hyperthyroidism, amenorrhea was described as early as 1840 by von Basedow. The most common manifestation is simple oligomenorrhea (decreased menstrual flow). Anovulatory cycles are very common. Increased bleeding may occur, but is rare in hyperthyroidism. Nowadays hyperthyroidism is diagnosed earlier than it once was, and so the clinical picture is generally milder. So, menstrual disorders are less common than in previous… 

Thyroid Status in Patients with Dysfunctional Uterine Bleeding in a Tertiary Care Hospital of Assam

It is seen that women with hypothyroidism had abnormal menstrual pattern, with menorrhagia or heavy menstrual bleeding being the commonest and thyroid dysfunction (subclinical or clinically evident) are becoming significantly important factors associated with DUB.

A prospective descriptive study of evaluation of menstrual disorders in thyroid dysfunction

Hypothyroidism is most common thyroid disorder followed by hyperthyroidism and subclinical hypothyroidistan is least common, and it is found that menstrual irregularities are more common in hypothy thyroid patients than hyperthy thyroid.

Hyperprolactinemia and Its Comparison with Hypothyroidism in Infertile Women

There is high incidence of hyperprolactinemia in infertile women as well high increased incidence of hypothyroidism in these women, which emphasizes importance of screening of prolactin and TSH levels inThese women.

The Pathophysiology of Amenorrhea in the Adolescent

The use of recombinant leptin to women with hypothalamic amenorrhea has been shown to restore LH pulsatility and ovulatory menstrual cycles and may improve the understanding of the pathophysiology of hypothalamic Amenorrhea in adolescents.

Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea.

Estimation of prolactin, fT3,fT4 and TSH should be included for diagnostic evaluation of amenorrhea because hyperprolactinemia with thyroid dysfunction may be contributory hormonal factor in patient with amenorrhoea.

A Study of Thyroid Dysfunction in Patients with a Provisional Diagnosis of Dysfunctional uterine bleeding

The thyroid function is evaluated in patients having abnormal menstrual bleeding from puberty to premenopausal age groups which will be interesting and justifiable and will help in further management of DUB.

Thyroid disease and female reproduction.

  • G. Krassas
  • Medicine, Biology
    Fertility and sterility
  • 2000

Excessive Uterine Bleeding in a Non-Compliant Patient With Profound Hypothyroidism: A Case Report and Review of the Literatures

The disturbance of hypothalamus-pituitary-ovarian axis due to the severe hypothyroidism is likely the major etiology for the excessive dysfunctional uterine bleeding.

A Study on Serum FSH, LH and Prolactin Levels in Women with Thyroid Disorders

The alteration in menstrual cycle and decreased reproductive performance of women are similar to polycystic ovarian disease and can be explained on the basis of altered hormone profile of LH, FSH and prolactin.

Menorrhagia as main presentation sign of severe hypothyroidism in a pediatric patient: a case report

It is described that low plasma levels of thyroid hormone can shift the hemostatic system towards a hypocoagulable and hyperfibrinolytic state and seem to lead to an increased bleeding risk.



[Rational hormonal diagnosis of oligomenorrhea].

A detailed diagnostic follow-up is recommended in all younger patients with ovarian disorders who need to preserve their reproductive potential, and should include hyperprolactinemia, hypo-/hyperthyroidism, hyperandrogenemic and hypoestrogenemic states and exclusion of primary ovarian failure.

Menstrual irregularities and lactation failure may precede thyroid dysfunction or goitre.

Interestingly, in 45% of cases with menstrual abnormality, the anomaly was antecedent to other clinical features by a variable period of two months to ten years, suggesting pharmacotherapy may be a superior alternative to surgical interventions like hysterectomy.

The menstrual pattern in thyroid disease.

Premenopausal female patients attending the Thyroid Clinic of the Massachusetts General Hospital over a twelve-month period, who showed definite clinical and laboratory evidence of hyperthyroidism or of myxedema, were included in this study.

[Rational hormone diagnosis in normocyclic functional sterility].

Examining the frequency of the different potential changes in hormone levels of an unselected group of female patients in a fertility clinic found that functional sterility was accompanied by hyperprolactaemia, which usually progresses and leads to secondary amenorrhoea which is the most severe symptom of ovarian insufficiency.

Menstrual disturbances in thyrotoxicosis *

The menstrual abnormalities in hyperthyroidism in women may be associated in almost 50% of the cases with hypomenorrhoea, oligomenor rhoea or amenorrhOEa and perhaps with reduced fertility.

The possible relationship between menorrhagia and occult hypothyroidism in IUD-wearing women

  • M. BlumG. Blum
  • Medicine
    Advances in contraception : the official journal of the Society for the Advancement of Contraception
  • 1992
It is concluded that any IUD-wearing woman suffering from menorrhagia may have occult hypothyroidism and a TRH test should be performed as the fefinitive diagnostic test.

Subclinical hypothyroidism and hyperprolactinemia.

A correlation between subclinic hypothyroidism-hyperprolactinemia and sterility is pointed out, in accordance with that has been reported in literature.

[Disorders of thyroid function and sterility in the woman].

Iodine avidity increased significantly with the increase in thyroid volume, but showed a tendency to lower values with increasing delta TSH-values and higher iodine avidity in women with thyroid enlargement, support recent studies, that factors other than TSH cause thyroid enlargements.

[Rational hormonal diagnosis of secondary amenorrhea].

Thyroid status should be evaluated in all women with functional amenorrhea; Androgen excess is much more frequent than was believed; hirsutism and/or acne by no means necessarily occur in cases of androgen excess.