Disturbances in Bone Largely Predict Aortic Calcification in an Alternative Rat Model Developed to Study Both Vascular and Bone Pathology in Chronic Kidney Disease.

@article{Neven2015DisturbancesIB,
  title={Disturbances in Bone Largely Predict Aortic Calcification in an Alternative Rat Model Developed to Study Both Vascular and Bone Pathology in Chronic Kidney Disease.},
  author={Ellen G Neven and Rida Bashir-Dar and Geert Dams and Geert J Behets and A. Verhulst and Monique M. Elseviers and P C D'haese},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 12},
  pages={2313-24}
}
Because current rat models used to study chronic kidney disease (CKD)-related vascular calcification show consistent but excessive vascular calcification and chaotic, immeasurable, bone mineralization due to excessive bone turnover, they are not suited to study the bone-vascular axis in one and the same animal. Because vascular calcification and bone mineralization are closely related to each other, an animal model in which both pathologies can be studied concomitantly is highly needed. CKD… CONTINUE READING
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