Disturbance of refinement of retinotectal projection in chick embryos by tetrodotoxin and grayanotoxin.

@article{Kobayashi1990DisturbanceOR,
  title={Disturbance of refinement of retinotectal projection in chick embryos by tetrodotoxin and grayanotoxin.},
  author={Toshi-aki Kobayashi and Hiyoshi Nakamura and Megumi Yasuda},
  journal={Brain research. Developmental brain research},
  year={1990},
  volume={57 1},
  pages={
          29-35
        }
}
The role of neuronal activity in the refinement of the retinotectal projection in chick embryos was studied using tetrodotoxin (TTX) which blocks sodium channels and grayanotoxin I (GTX) which opens the channels. Optic nerve fibers were traced by the fluorescent dye DiI. The toxins were injected into the eyeball during the refinement phase of retinotectal projection (either the 13th, 14th or 15th day of incubation). A tiny crystal of DiI was placed in the temporal part of the retina. In the… CONTINUE READING
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