Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.

@article{Miyazaki2006DisturbanceOC,
  title={Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.},
  author={Taisuke Miyazaki and Kouichi Hashimoto and Atsushi Uda and Hiroyuki Sakagami and Yoshitaka Nakamura and Shin-ya Saito and Miyuki Nishi and Hideaki Kume and Akira Tohgo and Izumi W Kaneko and Hisatake Kondo and Kohji Fukunaga and Masanobu Kano and Masahiko Watanabe and Hiroshi Takeshima},
  journal={FEBS letters},
  year={2006},
  volume={580 17},
  pages={4057-64}
}
By DNA cloning, we have identified the BSRP (brain-specific receptor-like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple-knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers… CONTINUE READING

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