Distributions of individual susceptibility among humans for toxic effects. How much protection does the traditional tenfold factor provide for what fraction of which kinds of chemicals and effects?

@article{Hattis1999DistributionsOI,
  title={Distributions of individual susceptibility among humans for toxic effects. How much protection does the traditional tenfold factor provide for what fraction of which kinds of chemicals and effects?},
  author={Dale B. Hattis and Prerna Banati and Rob L. Goble},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={895},
  pages={286-316}
}
A significant data base has been assembled on human variability in parameters representing a series of steps in the pathway from external exposure to the production of biological responses: contact rate (e.g., breathing rates/body weight, fish consumption/body weight); uptake or absorption (mg/kg)/intake or contact rate; general systemic availability net of first pass elimination and dilution; systemic elimination or half-life; active site availability/general systemic availability… CONTINUE READING

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