Distributions in protein conformation space: implications for structure prediction and entropy.

@article{Sullivan2004DistributionsIP,
  title={Distributions in protein conformation space: implications for structure prediction and entropy.},
  author={David C. Sullivan and Irwin D. Kuntz},
  journal={Biophysical journal},
  year={2004},
  volume={87 1},
  pages={113-20}
}
By considering how polymer structures are distributed in conformation space, we show that it is possible to quantify the difficulty of structural prediction and to provide a measure of progress for prediction calculations. The critical issue is the probability that a conformation is found within a specified distance of another conformer. We address this question by constructing a cumulative distribution function (CDF) for the average probability from observations about its limiting behavior at… CONTINUE READING

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