Distribution study of a synthetic ACTH analogue in rat tissue.

@article{Hirata1981DistributionSO,
  title={Distribution study of a synthetic ACTH analogue in rat tissue.},
  author={Masaharu Hirata and Shinya Futaguchi and Kunihiro Odaguchi and K Inouye and Akira Tanaka},
  journal={Acta endocrinologica},
  year={1981},
  volume={96 4},
  pages={
          464-9
        }
}
Tissue distribution of (Aib1, Lys17, 18, 19)-corticotrophin-(1-19)-nonadecapeptide amide (690024-S), iv injected to hypophysectomized rats, were surveyed by bioassay. Among the tissues examined. the largest amount of 690024-S was found in the liver during 3 h of search for the injection, while a higher concentration of the peptide per tissue weight was found in kidney. Though a small amount of 690024-S was detected in spleen, heart and lung at an early stage, it was not detectable in other… 
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Widespread presence of large molecular weight adrenocorticotropin-like substances in normal rat extrapituitary tissues.
TLDR
It is concluded that high molecular weight ACTH-like materials are widespread in normal rat extrapituitary tissues and are probably a precursor form of 4500 mol wt ACTH.
ACTH immunoactivity in normal rat tissues: modulation by hypophysectomy and adrenalectomy.
TLDR
Gel filtration showed that most of the increase in activity in kidneys of adrenalectomized rats corresponded to the 4.5 kD form of serum ACTH immunoactivity, suggesting that the activity increase in kidney was largely due to ACTH derived from blood.
Stabilization of a sustained release‐type injection vehicle for a synthetic corticotrophin analogue
provides evidence that, for reproterol, the inhibition of 3'5'-monophosphate phosphodiesterase nucleoside (PDE), which hydrolyses cAMP to AMP and which controls the intracellular concentration of…
ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing's syndrome.
TLDR
The patient received postoperative chemotherapy and has been disease-free for 6 years and is believed to be the first reported case of an ACTH-secreting pancreatic neuroendocrine tumor presenting as bilateral ovarian metastases.

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