Distribution patterns of over-represented k-mers in non-coding yeast DNA

@article{Hampson2002DistributionPO,
  title={Distribution patterns of over-represented k-mers in non-coding yeast DNA},
  author={Steven E. Hampson and Dennis F. Kibler and Pierre Baldi},
  journal={Bioinformatics},
  year={2002},
  volume={18 4},
  pages={513-28}
}
MOTIVATION Over-represented k-mers in genomic DNA regions are often of particular biological interest. For example, over-represented k-mers in co-regulated families of genes are associated with the DNA binding sites of transcription factors. To measure over-representation, we introduce a statistical background model based on single-mismatches, and apply it to the pooled 500 bp ORF Upstream Regions (USRs) of yeast. More importantly, we investigate the context and spatial distribution of over… CONTINUE READING

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