Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood.

@article{Gonzlez2007DistributionPO,
  title={Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood.},
  author={Miriam German Gonz{\'a}lez and Alfredo Cabrera-Socorro and Carlos Gustavo P{\'e}rez-Garc{\'i}a and James D. Fraser and Francisco J. L{\'o}pez and Rafael Alonso and Gundela Meyer},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={503 6},
  pages={790-802}
}
The expression of estrogen receptors (ERs) in the developing and adult human brain has not been clearly established, although estrogens are crucial for neuronal differentiation, synapse formation, and cognitive functions. By using immunohistochemistry, we have studied the distribution of ER alpha and ER beta in human cerebral cortex and hippocampus from early prenatal stages to adult life. ER alpha was detected in the cortex at 9 gestational weeks (GW), with a high expression in proliferating… CONTINUE READING