Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysis.

@article{Huneycutt1994DistributionOV,
  title={Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysis.},
  author={B S Huneycutt and I V Plakhov and Z Shusterman and Shirley M. Bartido and Alice Shih-hou Huang and Carol Shoshkes Reiss and Chiye J Aoki},
  journal={Brain research},
  year={1994},
  volume={635 1-2},
  pages={81-95}
}
Earlier studies have shown that intranasal instillation of vesicular stomatitis virus (VSV), a negative-sense RNA virus, in mice and rats can result in infection of the brain, hind-limb paralysis and death. Using an antiserum directed against VSV proteins, we sought to determine the potential neuronal and non-neuronal pathways VSV utilize, for central nervous system dissemination in BALB/c mice. Within 12 h following intranasal inoculation of VSV, VSV antigen could be detected in the olfactory… CONTINUE READING