Distribution of valproate to subdural cerebrospinal fluid, subcutaneous extracellular fluid, and plasma in humans: a microdialysis study.

@article{Lindberger2001DistributionOV,
  title={Distribution of valproate to subdural cerebrospinal fluid, subcutaneous extracellular fluid, and plasma in humans: a microdialysis study.},
  author={Martin Lindberger and Torbjōrn Tomson and Lars Wallstedt and Lars St{\aa}hle},
  journal={Epilepsia},
  year={2001},
  volume={42 2},
  pages={256-61}
}
We sought to study the time course of the distribution of valproate (VPA) to subdural cerebrospinal fluid (CSF) in relation to subcutaneous extracellular fluid (ECF) and plasma after a single oral dose and to study the distribution to these three compartments under steady-state conditions. Microdialysis was used to estimate unbound VPA concentrations in subdural CSF and subcutaneous ECF, and blood samples were drawn for estimation of total and unbound VPA plasma concentrations in four patients… CONTINUE READING

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