Distribution of urocortin 2 and urocortin 3 in rat brain.

  title={Distribution of urocortin 2 and urocortin 3 in rat brain.},
  author={Asuka Mano-Otagiri and Tamotsu Shibasaki},
  journal={Journal of Nippon Medical School = Nippon Ika Daigaku zasshi},
  volume={71 6},
Recently, urocortin(Ucn)2 and Ucn 3 showing high sequence homologies to corticotropin-releasing factor (CRF)have been discovered as members of CRF peptide family. Both peptides bind specifically to CRF2 receptor. We generated polyclonal antisera against Ucn 2 and Ucn 3 to define distribution patterns of these peptides in rat central nervous system. Many Ucn 2 neurons are present in both parvocellular and magnocellular divisions of the paraventricular nucleus(PVN)and a few Ucn 2 neurons exist in… CONTINUE READING

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